V. Carnevale, S. Raugei, C. Micheletti and P. Carloni
Convergent dynamics in the protease enzymatic superfamily
J. Am. Chem. Soc.128, 9766-9772 (2006)
ABSTRACT
Proteases regulate various aspects of the life cycle in all organisms by cleaving specific peptide bonds. Their action is so central for biochemical processes that at least 2\% of any known genome encodes for proteolytic enzymes. Here we show that selected proteases pairs, despite differences in oligomeric state, catalytic residues and fold, share a common structural organization of functionally relevant regions which are further shown to undergo similar concerted movements. The structural and dynamical similarities found pervasively across evolutionarily distant clans point to common mechanisms for peptide hydrolysis.