Ann. Comb. 3, 431-450 (1999).
Strategies for Protein Folding and Design
Cristian Micheletti, Flavio Seno, Amos Maritan, and Jayanth R. Banavar
Link to online article.
Fundamental challenges in molecular biology can be addressed by using
simple models on a lattice, where statistical mechanics and
combinatoric techniques can be employed. The basic premise is that it
is sensible to carry out tests of any proposed method on the simplest
of models in order to assess its validity before launching a
full-scale attack on realistic problems. In this paper we follow this
strategy and we present different efficient schemes to perform protein
design and to extract effective amino acid interaction potentials.