T. Keef, C. Micheletti and R. Twarock
Master equation approach to the asembly of viral capsids
J. Theor. Biol. 242, 713-721 (2006)
Link to online article.
The distribution of inequivalent geometries occurring during
self-assembly of the major capsid protein in thermodynamic equilibrium
is determined based on a master equation approach. These results are
implemented to characterize the assembly of SV40 virus and to obtain
information on the putative pathways controlling the progressive
build-up of the SV40 capsid. The experimental testability of the
predictions is assessed and an analysis of the geometries of the
assembly intermediates on the dominant pathways is used to identify
targets for anti-viral drug design.